Midline brain anomalies

with CATCH 22 syndrome to psychotic disorders. CATCH 22 syndrome is a developmental malformation caused by hemizygous deletion of 22qll chromosome which usually presents with cardiac malformations, thymic aplasia, cleft palate, hypocalcaemia and chromosome 22 deletion (Wilson et al, 1993). Recently, a high prevalence of both schizophrenia and bipolar spectrum disorders have been found in these people but the reason for this phenomenon has remained obscure (Murphy & Owen, 1996; Papolos et al, 1996). We present a subject with CATCH 22 syndrome, schizophrenia and multiple midline anomalies of the brain and discuss the implications of his neurological findings to the possible aetiology of his psychiatric symptoms.